Estrogen may reduce airway constriction in women patients with ...

Townsend and colleagues then asked whether estrogens could produce bronchodilation, and may the combination of commonly used bronchodilators and estrogens be used to produce an even greater bronchodilation? Laboratory studies using bronchial smooth muscle cells, they found that combined treatment with estradiol and the agonist isoproterenol , had a synergistic effect on the decrease in intracellular calcium and strength of more than two estradiol or isoproterenol alone. They also found that these effects may involve a common pathway signaling.The results will be presented at ATS 2010 International Conference in New Orleans.

Townsend, Department of Physiology, Mayo Clinic and Biomedical Engineering, where he is completing his Ph.D. What is less clear is whether sex steroids, particularly estrogen, are harmful or beneficial for lung function.

Our work has focused solely on acute exposure of estrogens and the observed dilatory effects, said Ms. Townsend. In other organs and disease states, estrogens can have complex effects on inflammation, cell signaling, and other important factors for asthma and inflammation of the airways Given our results, we can ask a series of questions to guide the Future research:. What is the effect of chronic exposure to estrogen on smooth muscle tone? There are interactions between estrogen and progesterone in the airway? Men and women differ in their response to sex steroids, in terms of tone of the airways ? Then a combination of inhaled 2-agonists and estrogen are more effective in controlling asthma, and possibly have a save-2 agonist?

Townsend and colleagues exposed cells and smooth muscle of airways isolated from samples of lung surgery in small doses comparable to physiological levels of estradiol in women. They found that acute exposure to concentrations of estradiol comparable to those experienced during the menstrual cycle of a woman reduced intracellular calcium in bronchial smooth muscle cells. In addition, small amounts of force production by estradiol significantly reduced the human respiratory tract that had been stimulated with bronchoconstrictor, indicating a greater bronchodilation.

?The rapid development of technologies for whole genome analysis to make it more feasible in the future,? said Dr. Otonkoski. ?You also need to further explore if other methods could reduce the amount of DNA damage generated during the generation of stem cells,? two investigators agreed.

After puberty, women tend to have more severe symptoms and exacerbations than men. Women also have changes in bronchial reactivity throughout their menstrual cycle, pregnancy, and soon.

Therefore, we decided to explore the effect of estrogen on calcium regulation in airway smooth muscle. Adjustment of football a key factor in determining bronchoconstriction said Ms. Townsend.

Since the symptoms of asthma have been documented to be worse when estrogen levels are lowest in late luteal phase, we hypothesized that estrogens facilitate bronchodilation, rather than coercion.

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